Hacker News Reader

I am unfamiliar with "epigenetic aging". Are you talking about methylation causing worse performance in one arena or another?

Immune atrophy and toxic accumulation I would read as being the terminal effects of decreased functionality as a result of error accumulation, no?

View on HN

The following page is written in a reasonably readable prose and lists all the currently accepted hallmarks of aging. Genomic instability is on the list, but many other things beside it.

https://www.lifespan.io/topic/why-we-age/

But there has been recent talk about adding five more:

https://www.lifespan.io/news/researchers-propose-five-new-ha...

Aging is complicated. Stuff like extracellular cross-linking of collagen through glycation cannot be reduced to genetic/epigenetic changes, and yet is obviously a huge problem for aged organisms.

Reply on news.ycombinator.com