I don't think there is a scientific consensus on this particular mechanism as a root of aging. There is a lot of stuff happening along like epigenetic aging, accumulation of various toxins and seemingly pre-programmed atrophy of immune system in mammals.
The only de-aging experiment that demonstrated some positive results in humans didn't touch genes at all. It was the TRIIM and TRIIM-X trial which attempted to rejuvenate the thymus and thus reinvigorate immunity. The subjects exhibit a lot of changes consistent with being a bit younger (a few years).