Don’t people still talk about “low seratonin levels?” I always found it suspect that we say someone’s levels are low without actually measuring them.
For ADHD, stimulants actually do treat it by fixing "low dopamine"… in specific areas of the brain. But "low dopamine" is also a description of Parkinson's disease.
But SSRIs don't work like stimulants do; they take a lot more than half an hour to take effect. We don't actually know how SSRIs work in the people where they do work.
Sorry, need to be an anecdote for you. Prozac makes me manic in about 5 hours. We know how SSRIs work, the problem is they are treating a symptom not the cause of depression which is immune dysfunction.
If SSRIs did not increase serotonin there would be no risk of them causing serotonin syndrome, and they do.
Yeaaaaa that's gonna be a serious "citations (plural and trustworthy) needed" from me there
https://www.nature.com/articles/s41398-023-02445-y
Here are the plurals….
https://scholar.google.com/scholar?as_ylo=2019&q=immune+syst...
If this is your best citation, then I don't know why you expect everyone to know about and be confident in this theory. And that's without even questioning whether bipolar and depression are the same thing.
Your search results are all over the place and don't show anything coherent.
https://www.cell.com/neuron/pdf/S0896-6273(20)30431-1.pdf
“It is now well established that dysregu- lation of both the innate and adaptive immune systems occur in depressed patients and hinder favorable prognosis, including antidepressant responses.”