ORMs are, for the most part, good at the CRUD operations - that is to say, they easily translate SELECT, UPDATE, INSERT and DELETE operations between conventional class objects and database rows.
Things they usually aren't very good at are when you start trying to do things that require a lot of optimization - it's very easy to have an ORM accidentally retrieve way more data than you need or to have it access a bunch of foreignkey data too many times (in Django you can thankfully preload the latter by specifying it in a queryset). That's less an issue for basic CRUD, but is an issue if you're doing say, mass calculation and only need one column and none of the foreignkey data for speed reasons.
Basically - an ORM is good but don't let yourself feel suffocated by it. If it's not a good fit for an ORM, then don't do it in the ORM, either use SQL code to do it in the DB server or do a simpler SELECT (in the ORM) and do the complex operation in your regular application before INSERTing it back in the db (if that's a goal for the operation anyway). If it's outside of the CRUD types of DB access already, the extra maintenance overhead you get from having non-ORM database code (if you're doing the SQL approach) in the application would be there anyway, you'd just get a very slow application instead of a hard error, and the latter is easier to troubleshoot (and often fix), while with the former you need to start pulling up profiling tools.