Toffoli and Margolus wrote a fine book about things you could do with their machine. It was more fun to read than Wolfram's later "New Kind of Science".
https://donhopkins.com/home/cam-book.pdf
CAM6 Simulator Demo:
https://www.youtube.com/watch?v=LyLMHxRNuck
Forth source code for CAM-6 hardware:
This isn't a CAM simulator, but I once wrote a little hack of a CA playground inspired by it. Table-driven in a similar way, user-scriptable with JS, includes neighborhoods like the Margolus neighborhood. https://github.com/darius/js-playground/blob/master/ca.js and the associated ca.html.