1 mg of anti-rabbit antibody (a common thing to use in a lot of biology experiments) is $225 [1]. Outside of things like standard buffers and growth medium for prokaryotes, this is going to be the cheapest thing you use in an experiment.
1/10th of that amount for anti-flagellin antibody is $372. [2]
A kit to prep a cell for RNA sequencing is $6-10 per use. That's JUST isolation of the RNA. Not including reverse transcribing it to cDNA for sequencing, or the sequencing itself. [3]
Let's not even reach things like materials science where you may be working on an epitaxial growth paper, and there are only a handful of labs where they could even feasibly repeat the experiment.
Or say something with a BSL-3 lab where there are literally only 15 labs in the US that could feasibly do the work, assuming they aren't working on their own stuff. [4]
[1] - https://www.thermofisher.com/antibody/product/Goat-anti-Rabb... [2] https://www.invivogen.com/anti-flagellin [3] https://www.thermofisher.com/order/catalog/product/12183018A [4] https://www.niaid.nih.gov/research/tufts-regional-biocontain...
[1]: if you have delivered telco code to Softbank you may have heard this sentence
I guess we should not talk about the Higgs before someone else builds a second one and replicates the papers.
And replication can be done by the same party (although an independent party is better), and that may mean many trials.
And do we even set policy based on existence or non-existent of higgs bosons?
I am particularly unhappy with soft sciences in terms of replication.