I've definitely considered going with a more tuned layout such as this but I feel like it would just make things harder in general, with little to show for it apart from an increase in raw APM. Escape being where it is makes sense, but it's not like I find myself needing to immediately depress it to switch modes. "Escape Classic" takes a moment to reach and depress, but those moments coincide with some sort of context switch that your brain probably also needs a moment to adjust to, so it works itself out.
Much how I imagine (probably incorrectly) switching to Dvorak might make other keyboards feel alien, the rearranged keys would be a hindrance unless I carry a keyboard with me everywhere and insist on using it. It's jarring enough switching from one laptop keyboard to another, and the differences there are typically minimal.