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When ajax supports POST file uploads, I might consider the extinction of iframe.

You should be able to get the file list from an input in the 'change' event and then upload a FormData object via XHR.

Exactly - this is currently the only reason we still use iframes in any capacity.

And WYSIWYG editing.

Are you talking about document.designMode? You can enable contentEditable on any element to enable editing for subset of the document.