Not really. e.g. caffeine and nicotine don’t have harmful side effects. Neither do spending time with your friends or loved ones.
Harmful effects of nicotine
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363846/
I'm sure even a cursory search for caffeine will reveal some harmful side effects as well. Especially for people with certain conditions
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445139/