Helium leaks are a nightmare. During my PhD I worked with a self-built dilution cryostat that would often have leaks in the custom-built Indium seals. To find the leaks you'd have to pump the cryostat to high vacuum, hook up a portable mass spectrometer tuned to Helium to the pump circuit and then spray different parts of the cryostat with Helium from a regular gas canister. The He would then get sucked in through the leak and show up on the mass spectrometer, which was coupled to a loudspeaker so it would cause a sound whose pitch increased with the measured He density. Once you found the leak you had to vent the entire system, remove the faulty seal and replace it with a new one. All seals were handmade, i.e. you took a small filament of Indium, placed it between the flange and the housing (after carefully cleaning everything with Acetone) and carefully screwed it shut, turning each screw only a tiny bit at each turn and going around all the screws until you could see the Indium squeeze out of the edges.

Even worse, some leaks would only show up when the system got cooled down to liquid Helium temperature. When that happened you were out of luck as you can't cool the system down to 4K before spraying it with Helium, so you had to just guess where the leak might be and replace all seals in that area until you found the right one. Going even deeper in temperature would eventually turn the He4 suprafluid, which means that it loses all internal friction. In that state it would squeeze through even the tiniest molecular cracks, so again if that happened you just had to redo all the seals and hope they would hold.