The issue with replacing Reddit is that you need millions of users to crowd-source all that information that has gone into every minor sub-reddit. I don't think it's sub-reddits like /r/askreddit, /r/pics or /r/politics that people would be missing in a Reddit clone. It's all the small specialized sub-reddit, where you could get help fixing a lawnmower or debate the finer points of the various aspect ratios of national flags.
For instance you mention "debate the finer points of various aspect ratios". Current social networks are not very good for actual debate, in fact the genesis of Sqwok can be traced to a live debate in r/worldnews where I grew tired of refreshing the page. Many of the alternatives popping up for both Twitter & Reddit are cloning the underlying data model and user interface without offering much more.
Sqwok is different in that it couples some of the familiar aspects of existing social networking with high quality instant messaging, designed from the ground up for live public debate and discussion in a new format. Still has a long way to go but I believe there's a place for it.
> The issue with replacing Reddit is that you need millions of users to crowd-source all that information
Reddit didn't start out with subreddits or millions of people, it was just a fun place to read the news.