I was practicing increasingly denser fog/low visibility ILS landings of the F-16 in DCS, on my TrackIR'd 32"x3 triple screen sim rig (with transducers for buffeting sensations etc).
With triples (and much more so with VR, I'll transition to a Crystal "soon") you do develop a semi/meta(?)-"physical" connection with the sim after a while.
At a point visibility got so reduced I would completely experience vertigo. Even though I told myself it's only a sim, just look at the instruments (and the F-16 has so many, including HUD with the ILS glidescope), my head would spin out and I'd completely bork the landing.
Only after several more hours was I able to do it (with visibility so bad that the runway would only pop out when right on top of it metres from the ground). It would take a lot more to get comfortable with it, but by that point I had enough and - I still have nightmares about it. :)
Can completely understand how cloud based vertigo in a real plane with your life on the line has killed and will continue to kill so many. Mad respect to the real pilots here who have mastered this.