pointer-events: none on an opaque container, with the FB 'like' button below it.
Edit: It seems like this is a largely solved problem for Facebook: http://forum.developers.facebook.net/viewtopic.php?id=93201&...
Could definitely still be a problem for other social/ad/affiliate networks though.
Most people will click just to see what it might be and not miss out. Then the video player says you have to click on some letters to prove you're not a robot (clever trick, people don't think much of it because it reminds them of CAPTCHAs)
The letters actually have Facebook Like button iframes on them with opacity set to 0. I edited the opacity on one of them with the Chrome Dev tools:
http://polyprograms.free.fr/tmp/FacebookLikeClickJacking.jpg
Unknowningly liking the video will create a story in your friends' feeds, who will in turn click to see and spread it to their friends. No real harm is done except for the spam and all the ad views generated.
This makes attacks such as these a little less worrying.