How can you say it's not new when it's literally in the release notes for yesterday's Firefox update?
> For at least the last couple of years (maybe longer, that's just how long I've used Firefox on Windows) some sites are hardcoded not to allow extensions to run on them.
Yes, the setting extensions.webextensions.restrictedDomains is old, and it applies to every extension, including uBlock Origin. The domains are all Mozilla. Here's the complete list:
accounts-static.cdn.mozilla.net,accounts.firefox.com,addons.cdn.mozilla.net,addons.mozilla.org,api.accounts.firefox.com,content.cdn.mozilla.net,discovery.addons.mozilla.org,install.mozilla.org,oauth.accounts.firefox.com,profile.accounts.firefox.com,support.mozilla.org,sync.services.mozilla.com