I've never seen anything even remotely hinting at region or geography in their product line other than geo-routing for load balancing products, headers with geo info for you to do something with, etc. They include the serving "POP" in headers for diagnostic purposes but other than that you have no idea.
Where do my Workers run? Don't know, don't care. They are substantially cheaper and offer better availability and response times than their region-based "cloud" competitors. Same for KV, D1, R2, and anything else they come up with as they move further and further in (out?).
One would expect with them having the ability to allocate supporting hardware dynamically and globally their cost basis is substantially better than having customer facing and controlled region-based resources that still need to be built out for product support (regardless of usage) AND maintain the excess capacity local to each region to be anywhere near "elastic".