I love the Django ORM. It's concise, generates good queries and just works.

However, there's a danger - for complex applications, you want neatly separated domain objects and data layer. Django makes it really easy to make your model your domain object, and at some point that starts to hurt.

But a large part of any app is just objects backed 1-on-1 by a database table, and CRUD actions on them. It's fine.

Just watch out for those parts where the separation is needed, and separate them.