For just momo or momentum traders that deal in extremely liquid trading instruments, microseconds can even make a difference. Our current feed from a US equity exchange is about 220 microseconds or .22 miliseconds - and we are on the "slow" side of things. The guys that actually read, process, send transactions usually go as far as using FPGAs even (some of the bigger firms)
That said - there are still lots of places in the market where opportunities exist!
Regarding the existing opportunities, It's interesting imagining a situation where opportunities did not exist, seemingly the market would either become completely random, and driven by luck, or remarkably stable. Most interestingly it crazy to imagine a market that has been optimized to complete stability. I wonder if that's the natural progression of things.