Buildings a mere 50 years ago probably have very poor insulation (and hence high heating/cooling environmental + monetary costs), have electrics that aren't considered safe today, have plumbing probably containing lots of lead, and are lacking amenities considered standard today (electrical outlet next to the bed for phone charging, mixer taps, etc). Those buildings probably won't resist fire for long, and probably won't be suitable for heat pump heating. Sound insulation probably won't be good, so you probably get woken by your neighbour having sex.
All those things are fixable for a cost, or livable with a hit to quality of life, the environment, the house owners health, etc.
If we assume that the requirements for a home continue to evolve, then we can see that something built today would be unlikely well suited for use in 50 years. Considering that, perhaps it's best to build something easy to disassemble and rebuild 50 years from now.