What problems exist that generate events or commands faster than 500 million per second? This is potentially the upper bar for 1 thread if you are clever enough.
Latency is the real thing you want to get away from. Adding more than one CPU into the mix screws up the hottest possible path by ~2 orders of magnitude. God forbid you have to wait on the GPU or network. If you have to talk to those targets, it had better be worth the trip.