This man knows exactly what he is talking about. He was responsible for designing the original AMD Athlon 64. He worked at apple to transition from Generic Samsung ARM SoC to their own Apple silicon which is the base for modern M1 Apple silicon. He worked for Intel (we'll see his work in Lunar Lake, Jim Keller's Royal Core Project). And most importantly he worked again at AMD and gave us Zen architecture.

I find a completely silly claim but I guess as a CEO you need to talk your book.

Here is another interview with Jim Keller where he explains why instruction sets doesn't matter that much:

https://www.anandtech.com/show/16762/an-anandtech-interview-...