He once asked Jim Keller 'What is Love?'.
His interview with Grant Sanderson is cathartic in that Grant has very little patience for that kind of questioning, when Lex goes on about 'isn't e^iπ so pretty', Grant responds to the effect 'not if you actually understand it, it's math'.
I saw a quote on reddit that does a great job helping me understand my distaste for these kinds of questions: 'The man who loves everything and everyone, loves only himself.'