I play even Windows 3.1 games that require 16-bit libraries just fine. Nothing special. Install and go. Maybe a bit of ye olde config for really old DOS games where you had to set up a sound card in a separate config tool from the game :). Some games may require you to right-click on the executable, go to Properties, and set the Compatibility Mode to an older version of Windows. This is built into XP itself. Honestly, I think I only have 1 or 2 total games that have ever required it.
Been doing this forever (15 years?) on both Intel Macs and x86 desktops for as long as I can remember. Moreover, this isn’t just my old memories — literally played a Windows 3.1/95 game (came out in 1994) this weekend while watching Le Mans.