No idea how people have more than one kid... at least in the bay area. I have one kid and the cheapest decent childcare I've found costs about $30k/year, and is only approx. half time. It ends at ~2pm, and is closed all summer and about one week per month on average. It's been a huge struggle to keep a career going under these circumstances.
Even at prices and hours like this, there are year long wait lists for spots in these. I've several times had to take my kid out of childcare (kicked out, or they went out of business) and had to hire a nanny full time for 6 mo to 1 year before I could find another childcare spot. At the time I was paying 110% of my take home income to have a nanny despite having a PhD in a high demand field, burning through my savings with hopes of finding another childcare spot without ending my career. Not sure how anyone else does this.
As of now, I WFH while watching my son alone about half of the hours, which is really hard. I feel like I am not giving him the attention he deserves, and it's really hard to focus.