My 49 inch 144hz monitor ran fine for this exact use case when I had an amd 3600 and Nvidia 1660. Is your work use case somehow more demanding than gaming?
I've read that to run higher end games at 4k you need something like an Nvidia 3070 or higher. I currently have a 2060-Super and it struggles at times with 2k/1440p. Probably go AMD next upgrade as they are reviewed to be better at 4k and have much better heat/power reqs.