Hacker News Reader

Comment by redkinght99 | Hacker News Reader

Taurine? I've been jacking myself full of that since Middle School! Thanks RedBull!

Jokes aside, This feels like one of "Wine is Good for you" In moderation and other fine point details. Not buying it.

Can't stop laughing. The day after is terrible, but with the aging factor relevated - here is the recipe of favorite anti-aging cocktail

Jäger Bomb

Ingredients 1 1/2 ounces Jägermeister Liqueur 1/2 (8.4-ounce) can Red Bull energy drink

https://www.thespruceeats.com/jager-bomb-recipe-759713

I've always enjoyed Jäger bombs half and half. Then again, no one survives living in Champaign, IL without getting well acquainted to Jägermeister.

I've was always partial to the Blue Guy at Kams.

jaeger has a history as a traditional alpine bitter of serving some sort of medicinal purpose. like chartreuse or absinthe, lots of the herbal ingredients inside sometimes helped soothe upset tummies, or in the case of wormwood, expel parasites and worms.

or a nice steak. 1 - 14oz steak, season with tiptop steak seasoning, grill 3-4mins per side on med heat. let rest 5 mins. enjoy.

The nice steak and its sides provide the essential… stomach lining… to cope with the jägerbomb

Octopus and squids works too. Buy boiled and/or pre-sashimi’d, open package, slice as needed and serve with soy sauce.

Somehow I hated them as a child. Maybe it was too much for my body back then.

> The median life span of taurine-treated mice increased by 10 to 12%, and life expectancy at 28 months increased by about 18 to 25%. A meaningful antiaging therapy should not only improve life span but also health span, the period of healthy living. We, therefore, investigated the health of taurine-fed middle-aged mice and found an improved functioning of bone, muscle, pancreas, brain, fat, gut, and immune system, indicating an overall increase in health span. We observed similar effects in monkeys.

I don't think any studies have shown red wine to have a clear casual impact like that, even just in mice.

10-12% of a mouse's life is 5 or 6 months. Assuming it's going to extend human lives by 7 years and not 6 months is being optimistic at best.

MSM media is always trying to convince people they can live longer if they stick with coffee, berries, dark chocolate and wine — as if those foods needed boosters. And if true I’m quite sure we’d have people out there living to 150…

People are very receptive and willing to share your articles around when you tell them they're better off keeping enjoying they current lifestyle.

They have an incentive to boost "forbidden pleasure" foods that are popular with their subscribers. The subscribers get an excuse to do what they are already doing, the article feels dramatic because of the fake controversy, and the article is a little more viral by pretending to tell people something secret or surprising.

You probably can live longer if you stick with coffee (black), berries (minus the food you put the berries on top of), dark chocolate (unsweetened), and wine (in strict moderation).

Alcohol is a carcinogen, so if you’re optimizing for “living longer” you should take exactly 0 mL a day.

If you’re optimizing for living happier, on the other hand…

Oxygen is a carcinogen, now what...

That’s why we recently decided to cut its presence in the atmosphere by dramatically increasing CO2.

But as usual, inhale in small amounts only. There might be a cure coming at some point, but don’t hold your breath.

:^)

Now do weed.

Genome-wide DNA methylation association study of recent and cumulative marijuana use in middle aged adults https://www.nature.com/articles/s41380-023-02106-y

And in general, if you’re smoking it…

There is no such thing as 0 tollerance. Don't believe the anti-alcohol hype. There is such thing as hormesis, for basically any poison.

Evidence for hormesis is not convincing.

That is not true. Hormesis is a fact.

Can you link to some evidence I may have overlooked?

Sure: https://scholar.google.com/scholar?q=hormesis

https://asomenopausia.com/booksmedbio/Hormesis%20-%20The%20D...

Dark chocolate isn't exactly the safest food, even unsweetened:

https://time.com/6243073/heavy-metals-dark-chocolate-food/

For those curious, here's the report linked in that article:

https://www.consumerreports.org/health/food-safety/lead-and-...

A similar problem exists with Polonium-210 uptake in tobacco... although no one ever called tobacco healthy or safe. I basically live on dark chocolate, wine, red meat and tobacco, so we'll see what gets me first.

I guess the would matter on where in the world too the cocoa was grown. In the Caribbean the soil wouldn't have heavy metals.

Add to that the high oxalate content in dark chocolate.

https://www.sciencedirect.com/science/article/abs/pii/S08891...

The third most common cause of death in the United States, at least before COVID was a thing, is "accidental self-inflicted injury."

Heart Disease and Cancer, most in old age, are the top two.

Making micro adjustments to your diet just doesn't stand a chance at making a meaningful difference.

I'd really like to see that category broken down by sobriety. The overwhelming majority of my accidental self-inflicted injuries have happened when I was drinking. Broken shoulder (let's have sex on the arm of this chair... oops, it has wheels), broken kneecap (running upstairs), partially severed thumb (sure, I'll just open this plastic case with a knife!)...

The suggestion you're replying to was basically "cut out a ton of extra sugar" which would quite likely have an impact on heart disease.

Instead of wine I'd go with resveratrol directly.

The people I know who talk about these items the most vocally also frequently have fast food.

> Jokes aside, This feels like one of "Wine is Good for you" In moderation and other fine point details. Not buying it.

I mean, pinot noir has a lot of resveratrol. You'd just need 750-1000 glasses daily.

Is that a challenge? Because my mother in law just calls that Thursday.

AFAIK, at this point resveratrol does not look promising.

David Sinclair wrote in "Lifespan"[1] that they extended mice lifespan by (iirc) something like 40% but amounts of resveratrol used was something like mentioned 750-1000 wine glasses daily when translated to humans.

While Wikipedia suggests that resveratrol is not proven to help with anything, I'm still taking 600mg in the morning, along with 600mg ALA and 100mg of CoQ10. Placebo is an effect, too.

[1] https://en.wikipedia.org/wiki/Lifespan%3A_Why_We_Age_%E2%80%...

https://www.youtube.com/watch?v=vGmmBJq0NNo

I think at this point Sinclair has lost a lot of credibility

Thank you. Saddening but informative.

I was chatting about resveratrol this very week with a colleague, ex pro athlete, writing about "Nutrition in Sports" for his PhD. Looking forward to discussing these findings with him.

The really interesting clincher wasn't the association of taurine with anti-aging, but the association of exercise with increased serum concentrations of taurine.

> Not buying it

What is there not to buy?

They tested it in mice and it increased lifespan, they never claimed it worked for humans in the study.

> To test whether taurine deficiency is a driver of aging in humans as well, long-term, well-controlled taurine supplementation trials that measure health span and life span as outcomes are required.

Did you read the abstract?

Unfortunately all the sugar is working in the opposite direction.

Do they actually have mice drink wine?

Reply on news.ycombinator.com