Perhaps- but if in situation 2, you pledged your house as collateral, the creditor can still come after it. Generally, if your business is new and unproven, the bank will require you to sign a personal guarantee- or even to put up your house as collateral. Which means that they can still come after it!
If your business gets the loan, with no collateral, and no personal guarantee, then if the business goes bankrupt, the creditors can't come after personal assets! If you are lucky enough to find a bank willing to lend you 100,000 with no collateral, then go for it!