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FollowingTheDao

Really frustrating there is no open access to this paper.

I carry four (as far as I know) rare and low frequency homozygous minor allele SNPs in RELN:

rs39335(G;G)

rs3914132(C;C)

rs7696175(C;C)

rs4298437(T;T)

And guess what? I have Bipolar Disorder Schizoaffective type and my therapists keep telling me I have Aspergers.

This gene seems to bind to zinc, and a deficiency of zinc is also found in Alzheimer's.

https://www.jneurosci.org/content/41/13/3025#:~:text=Inflamm....

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010690/

https://alzres.biomedcentral.com/articles/10.1186/s13195-021...

Zinc has helped me in many ways.

Since the mutation is a GAIN OF FUNCTION mutation, more zinc means less risk of Alzheimer's.

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It is open access though, and linked at the bottom of the article:

https://www.nature.com/articles/s41591-023-02318-3

Thanks, still cannot fine the SNP for the RELN-H3447R mutant though...

I believe it is rs201731543

Found it by going to the list of all alleles of that gene (https://ensembl.org/Homo_sapiens/Transcript/Variation_Transc...) and looking for one that changes the 3444th amino acid from an H to an R

Thank you! Too bad 23andMe does not pull that SNP.

How did you find these alleles?

I uploaded my 23andMe raw data to promethease.con and searched for the gene.

Can you recommend a zinc supplement? Preferably NSF or Mayo tested?

Zinc Sulphate is the hospital approved form. But zinc picolinate will work well too.

I take zinc sulfate. 220 mg with 50mg of elemental zinc.

That is rather high and may cause side effects for most people.

(Those are: tingling in fingers, vivid dreams, and especially bad nausea and stomach pain. Also higher testosterone and dramatically higher sex drive, though maybe you like that.)

I agree, and I don’t recommend anyone take zinc before getting their zinc levels tested. Or if they know they have genetic issues with zinc and zinc deficiency.

But the side effects from the zinc could be from a deficiency as well.

If you are low in serotonin and dopamine and take zinc, it will increase these, and since you were low for so long, the reaction to higher levels will be more pronounced. The increase in serotonin is usually what causes stomach upset, and diarrhea.

So it’s probably better for people who haven’t taken zinc who are deficient to start slowly.

...Zinc can increase dopamine? I wonder what it would do to someone with ADHD.

Probably help some of them:

https://www.nature.com/articles/s41598-021-94124-5

B6 increases dopamine so that might play a role as well.

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