I thought I read many years ago there is a concern with breathing regolith in. Because regolith is not kind of "smooth" like particles here on Earth, they can get stuck in the lungs causing various health issues.
ie. like asbestos causing lung cancer
Yes. The NASA reports that study the potential effects on health do conclude that due to its particle shape, size, and composition, the fine regolith particles pose a significant danger to human health in prolonged exposure.