They feel unnatural and unconventional and is something a large part of the population will be unable to relate to. Food is a very cultural thing.

We've also been educated to buy and prepare our own meals from the most natural/unprocessed ingredients as possible and avoid heavily industrialized/preprocess ingredients for health reasons.

Lab grown meat is the opposite of both of that.

I am just playing Devil's advocate here. I understand the appeal and potential environmental benefits as well.