If you’re primarily interested in static charts (or your interactivity is driven by external controls, such as drop-downs and sliders, where you can regenerate the chart as needed for interaction), then Plot is ready for use. On the other hand if you need direct manipulation interaction, such as brushing or painting dots in a scatterplot, then you might stick with Vega-Lite for now.
We’re working on tooltips now, and interaction next. There’s a PR here with an early sketch and demo video: https://github.com/observablehq/plot/pull/721