Big fan of D3.js and now there is Observable Plot! I am building several data visualization software for exploratory data analysis:
RATH, auto exploratory data analysis: https://github.com/Kanaries/Rath
GraphicWalker, embeddable data exploration component: https://github.com/Kanaries/graphic-walker
They are using vega-lite for now. But there is a limit of building more fancy and customized visualizations. It seems Plot has a more flexible layer based visualization system that can support larger design space.
Is Plot stable enough now to migrate from vega-lite based system to Plot based? Are there any large milestone or roadmap of Plot in future?