I think I presented a trade-off rather than undermining my own argument although I didn't really clarify that I guess.
Essentially you either focus 100% to design and implementing the design via any available technologies (cross-compatible or not) or settle for 80% (20% loss of design and vision from effort in ensuring compatibility).
Ultimately it depends how passionate you are about your design. Personally I would rather have 5 people absolutely fall in love with and be moved by my design/interface/experience rather than 100 people being able to simply 'view' it.