One of the best things I’ve configured with BTT is to remove the global Quit application (cmd+Q) and global Hide application (cmd+H) keybindings. I use cmd+W all the time to shut tabs and a slight miss click would close the entire app.
With Karabiner Elements you could also bind quit to double Cmd+Q, I do that for "important" apps where accidental quit is bad, but for others (or for apps that don't have tabs) I leave quit to a single Cmd+Q
cmd-Q can be disabled in System Preferences too. Handy! No more tears.