"The problem was the problem. Paul realized that what we needed to be solved was not, in fact, human powered flight. That was a red-herring. The problem was the process itself, and along with it the blind pursuit of a goal without a deeper understanding how to tackle deeply difficult challenges."

I think this is untrue: people were solving the right problem, but doing so with insufficient tools. MacCready's solution was to improve the tools, but other alternatives (for example, hiring a thousand engineers and building a thousand planes a year) would have found the same answer. Of course that answer would have come at a much higher cost and for this problem it would have been uneconomical, but there are plenty of domains where MacCready's approach would have been suboptimal.

"Iterate faster" is a good lesson that I think is probably applicable for all of us, but the temptation to solve tangential problems is a hard one to resist and often unnecessary.