Given that humans haven't adapted 100% to "raw water" after millennia of evolution, the odds aren't really in their favor.
> A study among expatriates in Nepal suggests that immunity may take up to seven years to develop—presumably in adults who avoid deliberate pathogen exposure.[18] Conversely, immunity acquired by American students while living in Mexico disappeared, in one study, as quickly as eight weeks after cessation of exposure.[19]
I suspect it's your gut flora that adapts; but it's not your DNA.
absence of evidence is not evidence of absence