Another way of looking at it is that sampling inherently does the mixing down to baseband. Although it may not be exactly the baseband you want if the spectrum isn't cleanly symmetric about a multiple of the sample frequency.
Another way of looking at it is that sampling inherently does the mixing down to baseband. Although it may not be exactly the baseband you want if the spectrum isn't cleanly symmetric about a multiple of the sample frequency.
In the sampling operation, all sinusoids are shifted down to the "natural baseband" by adding or subtracting some multiple of the sampling frequency that places the resulting frequency within +/- half of the sampling frequency. So for your example of 22kHz, that real frequency has two components: +22kHz that gets shifted down to -18kHz=22kHz-40kHz, and -22kHz that gets shifted up to +18kHz=-22kHz+40kHz.
Note that this "natural baseband" is an abstraction of our own invention. You can just as easily think of the spectrum as ranging from 0Hz to the sampling frequency f_s, rather than -f_s/2 to f_s/2. The fact that some prefer one over the other is precisely why fftshift exists.
If you add the additional constraint of the signal being "bandpass-limited" where, X(w) = 0 for A > abs(w) > B for some A, B, then yes, you can under sample.
And that's where the information-theory idea comes in where the amount of information contained in the band only "needs" 2X sampling rate to reconstruct perfectly.
You can think of aliasing being somewhat orthogonal to that in the sense that you need 2X bandwidth so you don't corrupt the signal, but 2X max frequency so you don't alias anything else into the signal. (I say this realizing that aliasing is what would cause the former signal corruption, hence "somewhat")