May I suggest that, if you have't already, you get a 23andme. "While light alcohol consumption has been associated with a decreased risk of AD in general [127], this relationship does not appear to hold in ApoE4 carriers. Consumption of any amount of alcohol may increase the risk of AD[Alzheimer's disease] for ApoE4 carriers [128,129,130]. In one study, both light and moderate alcohol consumption were associated with improvement in learning and memory for non-carriers, but with a decline in learning and memory for carriers [129]. Other studies found that ApoE4 carriers who consumed alcohol one or more times per month had a higher risk of AD than those who never consumed alcohol [128] and the risk of AD for carriers increased with increasing amounts of alcohol consumption [130] These data suggest that alcohol consumption should be limited, especially in ApoE4 carriers." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073598/