Nice qualifier about 'biological' there, was totally necessary to make your point, really. Because, you know, if you're a trans woman you totally won't get harassed in the Tenderloin. So insightful, you must have a deep understanding of both presenting as a woman and living near the Tenderloin.
Those burly fellows can look after themselves. We're talking about real women here, not blokes in drag.
I think you might get harassed as a trans woman in the Tenderloin, but the reasons would be different from the reasons you would get harassed as a cis woman.