Long before the FPS shooters started showing up I had the problem with mouse cables pulling on my hand and causing pain in the wrist. The solution was to use cable ties to fix the mouse cable to the keyboard cable so the mouse cable does a little loop up in the air and leaves enough space to move the mouse everywhere. Extra useful when you accidentally knock the mouse down because you are using an ergonomic mouse that is higher than you are used to. Instead of hitting the floor in three pieces, it just hangs in the air :-)