I use a small USB switcher box to let me control my personal machine and my work machine at the same desk. I also use a keyboard that lets me flip a switch to change between Mac/Windows layouts. It has been very helpful to let me cleanly separate work from leisure, without having to give up the ergonomics of my desk setup. The friction to switch is low enough that I don't feel tempted to keep work related stuff on my personal machine.
I used to have dual monitors, but now I use a super ultrawide 32:9 monitor. It required learning to use window managers since most OS's don't support multitasking setups like that, but I can use layouts now that I couldn't before. I also use PaperWM[1] with it and it feels particularly effective on ultrawides.