I don't know... from what I've used of Python it is pretty memory heavy and doesn't do well left alone unsupervised. I could be wrong but that was my experience trying various Py web frameworks.
My app servers were all $5 VPS with only nginx, PHP/php-fpm, and Memcached. PHP was cached, nginx assets were cached, and data was cached in RAM with Memcached which was updated from remote DB server on cache expire.
I would then stack as many of those behind a load balancer as needed (nginx as reverse proxy basically) and scaled up to serving 100's of terabytes of data monthly and billions of page views.
So while it was "$5 VPS" it was really a small cloud of them behind another $5 vps as a load balancer with a $25 database server supporting the data. Still cheaper than Amazon for equivalent loads.