The DDT (deduplication table) used to require ~1GB RAM for every 1TB data written over the life of the file system. Deleting data from the file system wouldn't remove the dedupe references, you'd have to recreate the pool entirely and start over with a new DDT.

However, there are now special devices that can be used stored to store DDT. Typically this is done with two SSDs configured as a mirrored vdev for the DDT metadata. This reduces the overhead on memory, but does cost some performance and still has the same limitation that the DDT size can only be reduced by re-creating the pool.