It's worth saying that GitHub also has GitHub AE, which has some requirements (e.g. 500+ heads) but is a lot better for paranoid administrators, offering stricter audit results (FedRAMP High is no joke), data residency, stricter auth requirements, etc etc.
I'd _imagine_ that such an environment is deployed as an isolated managed GitHub Enterprise instance, and at the very least in that environment I'd expect all data to be secured encrypted at rest.