You can still buy new motherboards with ISA slots. Lots of industries need these. https://duropc.com/product/r6029-4p5i-4
That board uses a chipset that has been out of production for 9 years.
The newest CPU it supports was released in 2017, and has been off the market for 3 years.
This open source design makes good use of TPM ports present in most modern motherboards, including current generation, thus it should bring ISA access for everyone, on the cheap.
I don’t think current generation motherboards are commonly carrying LPC interfaces having been replaced with eSPI.
The motherboard in the video is stretching the term modern being a Sandy Bridge era - ie a decade old.
This seems so messed up.