Thanks for the feedback. I use Museo for regular text in an attempt to differentiate from the 'default' styles. However, it should not bother you when reading.
http://i.imgur.com/D77Ey.png (the a's are especially choppy)
Chrome on Windows uses a different engine for rendering text than Firefox or IE. They're working on a fix: http://news.ycombinator.com/item?id=3523375