The fact is you really can't do much with a PCR machine. Sure, you can identify your friends boogers. But it only reduces one tiny aspect of overall cost. Add a centrifuge, a flow cytometer, a gel box, some incubators, and then maybe you have a functional 'garage' lab.
But again, you don't achieve much by having immediate in vitro sequencing. Not sure what the point is.
The real barrier then is literally funding and the capacity to do the research. And that's exactly what my startup is doing.