OpenPCR is a good example of frugal engineering applied to the space. I hope to see more attempts at making this hardware cheaper and accessible.
Regarding the spec on the Database. User friendliness would be a start, can you throw in what you would want to improve - I'm interested in your ideas?
The company "ion torrent" caught my eye regarding the in vitro DNA sequencing. It disrupts Halcyon Molecular and could cut the cost down even quicker.