It depends on what epistemological status you assign to the experiences of the trip. If the trip is access to a different part of you, or a different truth than you normally know, then integrating it is very valuable.
But if it's just random weird things that your neurons do while being poisoned, why bother to integrate it? Should I integrate the experience of having a stroke or a migraine? (On the other hand, in that case why bother to have the trip at all?)
And, is there any reason to suppose that poisoning your neurons should be a source of truth, or even of access to "a different part of you"?
I think the point being any altered sense of perception of routine in regular reality warrants some introspection, the +/- probably depends on how profound it is? You points are good. different part of you, who knows, some people say you're re-tuning the bring to access new vibrations that show alternative realities and dimensions. Lots of big questions here! :)
Just curious