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Awesome experience report, but

> it seems the reason it lasted so long is because I couldn’t vomit in the first place, so the “medecine” stayed with me longer

I highly doubt that, it was probably metabolized and out of your system in a few days max. What you describe are classical "afterglow" symptoms.

https://en.m.wikipedia.org/wiki/Afterglow_(drug_culture)

Afterglow is a layman's term but tells you nothing of the science. After the high does of amines (serotonin analog) which results in a drastic change serotonin receptor densities. It takes a while fro these receptors densities to return to normal.

DMT behaves as an agonist at both 5-HT2A and 5-HT2C receptors. There is nothing more to the magic than that.

P.S. I have the same experience as being on DMT and I do not take DMT and for some reason I am on disability for it. So tell me again how this is beneficial?

I'm confused. What are you on disability for? Surely not for using DMT...

Sounds like they are on disability because they experience DMT-like effects without taking DMT.

Yes. I have schizo-affective bipolar disorder and I often have hallucinations.

I see in another comment you said you cured your schizo-affective Bipolar disorder without medication. Do you mind if I ask how you did that? I have a condition (probable personality disorder with extreme anxiety) and I've been taking methadone to get off of opioids for about 4 years now, and I noticed that when I go down on my dose, my symptoms start to flare up. So in essence I'm keeping it in check with the same class of drugs I was using to self-medicate with. I have done DMT and it did do wonders for me (went from daily suicidal ideation to almost no suicidal thoughts in almost a decade) but I think there has to be more.

If the phenomena is complex even when the mechanism is glossable, you are missing out in descriptive detail when you imply it is "just" an agonist on those receptors. That itself should be mind-boggling. You have those receptors in your stomach.

Being able to dip into an experience at one’s leisure is worlds different than being stuck with that experience due to a long term condition.

Why? I mean I can make up all the stories I want, right? I can call myself a shaman or a mystic, but no one cares. But you get McKenna tripping out wholly on drugs and somehow he is special and knows everything?

I know my worth but no one cares, they will not listen to me because of my overly creative mind. Very few people here can understand the connection I make.

It made me a better person because it had to. It forced me to self reflect. Why do you all need drugs to do that?

Since you try to bring scientific rigor into the discussion, could you point me to some evidence that the epiphenomal effects of the named condition are clearly merely caused by a temporary increase in receptor densities?

Having taken several neuroscience classes, I think that claim is a gross oversimplification and an overly reductionist take on the incredibly complex topic at hand.

> So tell me again how this is beneficial?

I can't answer that question as I have made no statement about any purported benefits or lack thereof.

> could you point me to some evidence that the epiphenomal effects of the named condition are clearly merely caused by a temporary increase in receptor densities?

When someone takes prozac and tries to stop, they have withdrawal effects. Prozac increases serotonin which increases receptor density.

https://link.springer.com/article/10.1023/A:1014862808126

Why should this be any different from DMT?

I have been studying neurobiology for 20 years. I thought a lot of things that I found out were wrong.

> https://link.springer.com/article/10.1023/A:1014862808126

1. The results of this study are about long-term treatment, not a single dose.

2. The study makes absolutely zero claims about the epiphenomenal effects of receptor site increases/decreases, as far as I can see. That is your interpretation (with no evidence.) Sure, people describe withdrawal effects after quitting a drug that made them feel good, and there might be a correlation with decreasing receptor sites and those withdrawal symptoms, but you have not established any causal links, the main point I asked you about.

3. In the original comment you associated the generally positive effects that the OOP described as a consequence of decreasing serotonin receptor sites. Yet then you make a claim based on this study that decreasing receptor sites cause negative withdrawal effects. It very much seems like those two claims contradict themselves? Honestly a bit confused here what you're trying to say.

> I have been studying neurobiology for 20 years.

Well that's impressive. May I ask what your h-index is?

> 1. The results of this study are about long-term treatment, not a single dose.

DMT acts on the HTR2A and HTR2C receptors. When you activate HTR2C receptors at high levels the nerves respond by changing the number HTR2C receptors. This is called having an "effect of receptor density".

You can read about it in this study: (I know what you are going to say, that this proves one cannot get habituated to DMT But that is wrong adn you will need to read the second study to understand why.

https://www.sciencedirect.com/science/article/abs/pii/S00913...

Because drug efficacy changes with receptor density and cellular microenvironment, we also examined the properties of DMT in native preparations using a behavioral and biochemical approach."

One difference was evident in that the 5-HT2C, but not the 5-HT2A, receptor showed a profound desensitization to DMT over time. This difference is interesting in light of the recent report that the hallucinogenic activity of DMT does not tolerate in humans and suggests the 5-HT2C receptor plays a less prominent role in the action of DMT.

https://www.cureus.com/articles/62522-5-ht1a-and-5-ht2a-sign...

Furthermore, abnormal receptor density ratios are strongly associated with positive and negative symptom severity, which are typically assessed using the Scale for the Assessment of Negative Symptoms

In addition, Hurlemann et al. (2007) proposed that 5-HT2A receptor density was also decreased in the At-Risk Mental State patient subgroup, regardless of conversion to psychosis [4]. The progressive decline in subcortical 5-HT2A receptor density could provide an indicator of conversion to schizophrenia.

> That is your interpretation (with no evidence.)

That is what is called a hypothesis. Do you ever have an original insight or do you just walk around nixing creative thought because no one ever thought of it before?

I mean you focus only on the study and you cannot see the connection because you so myopic.

> Well that's impressive. May I ask what your h-index is?

It is people like you who keep science in the dark ages.

I cured my schizo-affective Bipolar disorder without medication. What have you done?

interesting, i definitely felt an afterglow as well, hard to know exactly what caused it.

> - I got more confrontational which almost got me into fights, but also got me laid

These systems are likely deeply tangled up in your biology. Robert Sapolsky has a Stanford lecture series on this: https://www.youtube.com/watch?v=NNnIGh9g6fA

Well worth a watch!

Sapolsky's "Behave" is a great book in my opinion. The series is also very interesting!

didn't even know this was a field of research, looks fascinating

How can it be deeply tangled up in his biology if it can be changed by taking a drug?

biology is just applied chemistry

Do you think you could shift back into that "10x more confident self" consciously without the Ayahuasca?

I definitely tried but couldn't. It always felt like I was forcing it (becoming aggressive) and not natural like after the ayahuasca.

Fake it till you make it, killer.

Interesting read, but you would think that resolving some of that past trauma that was hidden would allow you to transition into a state that isn't your old "normal", but a nice halfway between your arrogant 10x present self and your old self chained by trauma.

Perhaps this experience when bundled with a professional could have great impacts that are permanent, as long as you don't start fighting the therapist I suppose! The opposite could also happen, I don't know. Would be interesting to see studies on this.

actually yeah, some of the friends I did it with actually mixed it with therapy and did dozens of sessions and it helped them tremendously.

You could consider doing more drugs.