> upending the economic mainstay of that whole region would be done "easily"
Change the incentives (remove animal subsidies), and the problem will solve itself.
There is a big demand for plant based protein now ... we know how to grow peas, beans, lentils ... however it's not profitable to do so now because we continue to subsidize animal agriculture (one of the most harmful things we can do to the environment) with obscene amount of money. That's the main reason plant-based cheeses cost 3x more than cow-milk-based, although it should be other way around.
> crop that is profitable (without subsidies), suited to the region, and also doesn't require pesticides that affect insects would not be easy
Easy is not the important part. Easy led us to the hell (or purgatory), where we currently are.
Those problems you're writing about can be solved with biodiversity. Let's imagine smaller fields, with different crops, interplanted with trees and shrubs to enable a lot of life [0], and you won't have problems with mice or bugs, because diversity will take care of any infestations.
If you're interested how to farm economically without pesticides/herbicides, may I suggest movie The Biggest Little Farm (2018), where the role of biodiversity is nicely illustrated.
[0] https://fotobanka.chrudimskenoviny.cz/sites/default/files/im...
[1] https://www.imdb.com/title/tt8969332/